Does your kid have an MTHFR mutation colloquially known as the Mother F’er gene?

The MTHFR gene regulates the enzyme methylenetetrahydrofolate reductase which is involved in methylation of B vitamins which are essential cofactors for many enzymatic pathways.

High levels of homocysteine and low levels of B vitamins such as B6, folate (B9) and B12 occur which can lead to many health issues such as cardiovascular disease, depression, anxiety, schizophrenia, miscarriages, and pregnancies with neural tube defects.

Some reports have up to 98% of kids with autism having the mutation.

The two mutations seen that can lead to reduced MTHFR activity are C677T and A1298C.

Reduced activity of MTHFR leads to decreased formation of methylfolate and methyl B12 which are needed to form brain neurotransmitters- dopamine and serotonin- to regulate mood, attention, behaviors, communication, learning, and movement.

In addition, glutathione, one of the most potent antioxidants and detoxification molecules in the body, is reduced from an MTHFR mutation; therefore, detoxification can be impaired.

There’s genetic testing for MTHFR available through many companies such as 23andme.

Treatment typically is with methylfolate or folinic acid to provide the methylated form of folate since the body’s methylation’s ability is diminished.

With some kids, we see dramatic changes with folinic acid or methylfolate supplementation.

Support is sometimes also needed with methylB12 and glutathione.

In the Autism Healing Program, MTHFR is addressed since it is such a common finding amongst our kids.

You can schedule a complementary session at https://myhopewellness.satoriapp.com/offers/268129-discovery-session to review MTHFR and discuss other underlying factors that could be affecting your child and how the program can benefit them.